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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
2006 3
2007 2
2008 2
2009 6
2010 8
2011 16
2012 27
2013 29
2014 22
2015 22
2016 18
2017 19
2018 13
2019 11
2020 11
2021 9
2022 5
2023 7
2024 5

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199 results

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Page 1
Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling.
Huang Z, Rui X, Yi C, Chen Y, Chen R, Liang Y, Wang Y, Yao W, Xu X, Huang Z. Huang Z, et al. J Exp Clin Cancer Res. 2023 Mar 11;42(1):60. doi: 10.1186/s13046-023-02618-z. J Exp Clin Cancer Res. 2023. PMID: 36899380 Free PMC article.
RESULTS: We identified lipocalin-2 (LCN2), which is upregulated in OSCC metastasis and EGFR resistance. ...Mechanistically, LCN2 binds EGFR and enhances the recycling of EGFR, thereby activating the EGFR-MEK-ERK cascade. ...
RESULTS: We identified lipocalin-2 (LCN2), which is upregulated in OSCC metastasis and EGFR resistance. ...Mechanistically, …
Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy through SIRT3-mediated TFAM deacetylation.
Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge Y, Ma T, Wu J, Li L, Sun M, An S, Li J, Huang Q, Gong S, Zhang J, Chen Z, Zeng Z. Deng Z, et al. Autophagy. 2024 Jan;20(1):151-165. doi: 10.1080/15548627.2023.2252265. Epub 2023 Aug 31. Autophagy. 2024. PMID: 37651673 Free PMC article.
AKI: acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated glomerular filtration rate; H&E: hematoxylin and eosin staining; LCN2/NGAL: lipocalin 2; LPS: lipopolysaccharide; LTL: lotus tetrag …
AKI: acute kidney injury; ATP: adenosine triphosphate; BUN: blood urea nitrogen; CLP: cecal ligation and puncture; eGFR: estimated gl …
Kidney Biomarkers and Decline in eGFR in Patients with Type 2 Diabetes.
Garlo KG, White WB, Bakris GL, Zannad F, Wilson CA, Kupfer S, Vaduganathan M, Morrow DA, Cannon CP, Charytan DM. Garlo KG, et al. Clin J Am Soc Nephrol. 2018 Mar 7;13(3):398-405. doi: 10.2215/CJN.05280517. Epub 2018 Jan 16. Clin J Am Soc Nephrol. 2018. PMID: 29339356 Free PMC article.
BACKGROUND AND OBJECTIVES: Biomarkers may improve identification of individuals at risk of eGFR decline who may benefit from intervention or dialysis planning. ...Cox proportional regression was used to assess associations with a 50% decrease in eGFR, stage 5 CKD ( …
BACKGROUND AND OBJECTIVES: Biomarkers may improve identification of individuals at risk of eGFR decline who may benefit from interven …
G-4 inhibits triple negative breast cancer by inducing cell apoptosis and promoting LCN2-dependent ferroptosis.
Sun G, Wang J, Liu F, Zhao C, Cui S, Wang Z, Liu Z, Zhang Q, Xiang C, Zhang Y, Galons H, Yu P, Teng Y. Sun G, et al. Biochem Pharmacol. 2024 Apr;222:116077. doi: 10.1016/j.bcp.2024.116077. Epub 2024 Feb 21. Biochem Pharmacol. 2024. PMID: 38395264
Flow cytometry and immunoblotting showed that G-4 not only arrested the S phase of the cell cycle, but also induced apoptosis in TNBC cells via the mitochondrial pathway through inhibiting epidermal growth factor receptor (EGFR), AKT and MAPK pathways. In addition, G-4 ind …
Flow cytometry and immunoblotting showed that G-4 not only arrested the S phase of the cell cycle, but also induced apoptosis in TNBC cells …
Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer.
Rashid NS, Boyd DC, Olex AL, Grible JM, Duong AK, Alzubi MA, Altman JE, Leftwich TJ, Valentine AD, Hairr NS, Zboril EK, Smith TM Jr, Pfefferle AD, Dozmorov MG, Harrell JC. Rashid NS, et al. Sci Rep. 2022 Dec 8;12(1):21248. doi: 10.1038/s41598-022-25541-3. Sci Rep. 2022. PMID: 36482068 Free PMC article.
Comparison of all three data types revealed five genes that were upregulated across all erlotinib-resistant samples: IL19, KLK7, LCN2, SAA1, and SAA2. Of these five genes, LCN2 was most abundantly expressed in triple-negative breast cancers, and its knockdown restor …
Comparison of all three data types revealed five genes that were upregulated across all erlotinib-resistant samples: IL19, KLK7, LCN2 …
Kidney Injury Marker 1 and Neutrophil Gelatinase-Associated Lipocalin in Chronic Kidney Disease.
Castillo-Rodriguez E, Fernandez-Prado R, Martin-Cleary C, Pizarro-Sánchez MS, Sanchez-Niño MD, Sanz AB, Fernandez-Fernandez B, Ortiz A. Castillo-Rodriguez E, et al. Nephron. 2017;136(4):263-267. doi: 10.1159/000447649. Epub 2016 Oct 22. Nephron. 2017. PMID: 27771693 Free article. Review.
However, there are gaps in knowledge regarding the risk stratification of elderly patients with eGFR 45-60 ml/min/1.73 m2 and of younger patients with higher eGFR but physiological albuminuria. ...In general, neither urinary KIM-1 nor urinary NGAL (uNGAL) outperform …
However, there are gaps in knowledge regarding the risk stratification of elderly patients with eGFR 45-60 ml/min/1.73 m2 and of youn …
Adverse Crosstalk between Extracellular Matrix Remodeling and Ferroptosis in Basal Breast Cancer.
Desterke C, Cosialls E, Xiang Y, Elhage R, Duruel C, Chang Y, Hamaï A. Desterke C, et al. Cells. 2023 Aug 30;12(17):2176. doi: 10.3390/cells12172176. Cells. 2023. PMID: 37681908 Free PMC article.
Through text-mining, some ferroptosis-significant adverse-selected genes shared citations in the domain of ECM remodeling, such as TNF, IL6, SET, CDKN2A, EGFR, HMGB1, KRAS, MET, LCN2, HIF1A, and TLR4. A molecular score based on the expression of the eleven genes was …
Through text-mining, some ferroptosis-significant adverse-selected genes shared citations in the domain of ECM remodeling, such as TNF, IL6, …
Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway.
Shi C, Wang C, Fu Z, Liu J, Zhou Y, Cheng B, Zhang C, Li S, Zhang Y. Shi C, et al. Pharmacol Res. 2024 Mar;201:107088. doi: 10.1016/j.phrs.2024.107088. Epub 2024 Feb 1. Pharmacol Res. 2024. PMID: 38295916 Free article.
Almonertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is highly selective for EGFR-activating mutations as well as the EGFR T790M mutation in patients with advanced non-small cell lung cancer (NSCLC). ...Our findi …
Almonertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, is highly selective for EGFR …
Molecular pathways of chronic kidney disease progression.
Bienaimé F, Canaud G, El Karoui K, Gallazzini M, Terzi F. Bienaimé F, et al. Nephrol Ther. 2016 Apr;12 Suppl 1:S35-8. doi: 10.1016/j.nephro.2016.02.009. Epub 2016 Mar 10. Nephrol Ther. 2016. PMID: 26972095 Review.
In particular, we examine the role of mammalian target of rapamycin complex (mTORC)/serine-threonine protein kinase AKT, epidermal growth factor receptor (EGFR) and unfolded protein response pathways, as well as the pleiotropic function of Lipocalin 2. ...
In particular, we examine the role of mammalian target of rapamycin complex (mTORC)/serine-threonine protein kinase AKT, epidermal growth fa …
199 results